HSPC150抗体;HSPC150 Antibody—艾普蒂 新品

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of HSPC150 expression in HeLa cell lysate.    

  
  

**Background of HSPC150 Antibody**

The HSPC150 antibody targets the Hematopoietic Stem/Progenitor Cell 150 (HSPC150) protein, also known as UBE2Q1. a member of the ubiquitin-conjugating enzyme (E2) family. This protein is implicated in the ubiquitin-proteasome system, which regulates protein degradation, cell cycle progression, and apoptosis. HSPC150 was initially identified in hematopoietic stem/progenitor cells but is expressed in various tissues, suggesting broader biological roles.

Structurally, HSPC150 contains a conserved ubiquitin-conjugating (UBC) domain at its N-terminus, critical for its enzymatic activity. Studies highlight its involvement in cancer biology, with upregulated expression observed in malignancies like breast cancer, colorectal cancer, and glioblastoma, correlating with tumor progression and therapeutic resistance.

HSPC150 antibodies are essential tools for detecting the protein’s expression and localization via techniques such as Western blotting, immunohistochemistry (IHC), and flow cytometry. Research using these antibodies has helped elucidate HSPC150’s interaction with E3 ubiquitin ligases and substrates, shedding light on its regulatory mechanisms in cellular processes.

Despite its known associations, HSPC150’s precise physiological and pathological functions remain under investigation. Ongoing studies aim to clarify its role in stem cell maintenance, oncogenesis, and as a potential biomarker or therapeutic target. The HSPC150 antibody thus serves as a critical reagent in both basic research and translational oncology.