LunaticFringe抗体;LunaticFringe Antibody—艾普蒂 新品

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     Western blot analysis of Lunatic Fringe expression in HeLa cell lysate.    

  
  

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     Immunofluorescent analysis using the Antibody at 1:500 dilution.    

  
  

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     Immunofluorescent analysis using the Antibody at 1:50 dilution.    

  
  

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     Immunofluorescent analysis using the Antibody at 1:150 dilution.    

  
  

LunaticFringe (LFNG) is a glycosyltransferase encoded by the *LFNG* gene, belonging to the fringe family of proteins that modulate the Notch signaling pathway. It catalyzes the addition of N-acetylglucosamine (GlcNAc) to O-fucose residues on Notch receptors, fine-tuning Notch-mediated cell-cell communication critical for embryonic development, tissue homeostasis, and cell fate determination. LFNG is particularly notable for its role in somitogenesis, neurogenesis, and limb development, where precise Notch signaling regulation is essential.

Antibodies targeting LunaticFringe are valuable tools in developmental biology and disease research. They enable the detection and localization of LFNG protein in tissues or cultured cells, aiding studies on its expression patterns and functional interactions. Such antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers also employ them to investigate LFNG dysregulation in diseases, including congenital scoliosis (linked to *LFNG* mutations) and cancers, where aberrant Notch signaling contributes to tumor progression or metastasis. Many commercially available LFNG antibodies are raised in rabbits or mice against specific epitopes, with validation in knockout models to ensure specificity. Understanding LFNG's role through antibody-based approaches continues to shed light on developmental disorders and potential therapeutic targets in Notch-driven pathologies.