GABAAReceptorbeta2抗体;GABAAReceptorbeta2 Antibody—艾普蒂 新品

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     Western blot analysis of GABA A Receptor beta 2 expression in A549 cell lysate.    

  
  

The GABA_A receptor beta2 antibody is a specialized tool used to detect the beta2 subunit of the gamma-aminobutyric acid type A (GABA_A) receptor, a key ligand-gated ion channel in the central nervous system. GABA_A receptors mediate inhibitory neurotransmission by facilitating chloride ion influx upon GABA binding, which hyperpolarizes neurons and reduces excitability. These receptors are pentameric structures, typically composed of combinations of alpha, beta, gamma, delta, or epsilon subunits. The beta2 subunit plays a critical role in receptor assembly, synaptic clustering, and functional modulation, influencing pharmacological properties and synaptic plasticity.

Antibodies targeting the beta2 subunit are widely used in neuroscience research to study receptor distribution, expression levels, and alterations in neurological or psychiatric disorders such as epilepsy, anxiety, and schizophrenia. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize beta2-containing receptors in brain tissues or cultured cells. Validated antibodies help investigate beta2-specific contributions to receptor trafficking, post-translational modifications, or interactions with drugs like benzodiazepines. Dysregulation of beta2-containing GABA_A receptors has been implicated in neurodevelopmental conditions and addiction mechanisms, making this antibody essential for probing inhibitory signaling pathways and therapeutic targets. Proper validation ensures specificity, often confirmed via knockout controls or peptide blocking assays.