HistoneH2A(monomethylK118)抗体;HistoneH2A(monomethylK118) Antibody—艾普蒂 新品

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     Western blot analysis of Histone H2A (mono methyl K118) expression in HeLa cell lysate.    

  
  

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     All lanes use the Antibody at 1:5K dilution for 1 hour at room temperature.    

  
  

The histone H2A monomethyllysine 118 (H2A monomethylK118) antibody is a specialized tool used to study post-translational modifications of histone H2A, a core component of nucleosomes. Histone H2A plays a critical role in chromatin structure and gene regulation, and its lysine residues undergo various modifications, including methylation, which influence epigenetic signaling. Monomethylation at lysine 118 (K118) is a specific epigenetic mark associated with transcriptional regulation, DNA repair, and chromatin remodeling. This modification is dynamically regulated by histone methyltransferases and demethylases, contributing to the activation or repression of target genes depending on cellular context.

The H2A monomethylK118 antibody enables the detection and localization of this modification in cells or tissues using techniques like chromatin immunoprecipitation (ChIP), immunofluorescence, or Western blotting. Researchers employ it to investigate its role in processes such as cell differentiation, cancer progression (where aberrant histone methylation is common), or responses to DNA damage. Specificity validation, including knockout controls or peptide competition assays, is essential to confirm its reliability, as cross-reactivity with similar histone marks can occur. Understanding H2A monomethylK118 dynamics provides insights into epigenetic mechanisms underlying development, disease, and potential therapeutic targets.