PAR6抗体;PAR6 Antibody—艾普蒂 新品

The PAR6 (Partitioning Defective 6) antibody is a key tool for studying the PAR6 family of proteins, which are critical regulators of cell polarity. PAR6 proteins (encoded by PARD6A, PARD6B, and PARD6G in humans) are scaffold components of conserved polarity complexes, primarily interacting with PAR3. atypical protein kinase C (aPKC), and Cdc42 to establish and maintain apical-basal polarity in epithelial cells. They play essential roles in diverse biological processes, including asymmetric cell division, tight junction formation, and neuronal development. Structurally, PAR6 contains PDZ and semi-LIM domains that mediate protein-protein interactions. Dysregulation of PAR6 signaling is linked to cancer metastasis, neurological disorders, and developmental defects. The PAR6 antibody detects specific isoforms or pan-PAR6 proteins in applications like Western blotting, immunofluorescence, and immunohistochemistry. Researchers use it to investigate polarity mechanisms, epithelial-mesenchymal transition (EMT), and disease-associated alterations in PAR6 expression or localization. Its specificity varies depending on the immunogen design, often targeting conserved regions or isoform-unique sequences. Validating PAR6 antibodies requires careful consideration of cross-reactivity due to high homology among isoforms and species orthologs (e.g., human, mouse, rat).