MastCellChymase抗体;MastCellChymase Antibody—艾普蒂 新品

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     Western blot analysis of Mast Cell Chymase expression in Human small intestine lysate.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

Mast cell chymase (also known as mast cell protease 1) is a serine protease primarily stored in the secretory granules of mast cells, playing a key role in inflammatory and tissue-remodeling processes. As a mediator released during mast cell activation, chymase participates in degrading extracellular matrix components, activating cytokines (e.g., IL-1β, IL-18), and modulating vascular permeability. Its dysregulation is implicated in pathologies like asthma, fibrosis, cardiovascular diseases, and allergic reactions.

Antibodies targeting chymase are essential tools for studying mast cell biology and disease mechanisms. These antibodies enable precise detection of chymase expression, localization, and activity in tissues or biological fluids. Commonly used in immunohistochemistry, Western blotting, and ELISA, they help identify mast cell populations in pathological states (e.g., mastocytosis, chronic inflammation) and assess therapeutic responses. Monoclonal and polyclonal variants exist, with some clones (e.g., CC1. B7) recognizing specific epitopes or active/inactive forms.

Research leveraging chymase antibodies has advanced understanding of its dual roles—both protective (pathogen defense, wound healing) and harmful (tissue damage, fibrosis). Recent studies also explore chymase inhibitors as potential therapies, underscoring the antibody's value in drug development and diagnostic applications.