PAR2抗体;PAR2 Antibody—艾普蒂 新品

+ +

•  

   

     Western blot analysis of PAR2 expression in K562 cell lysate.    

  
  

PAR2 (Protease-Activated Receptor 2) is a G protein-coupled receptor activated by proteolytic cleavage of its extracellular N-terminal domain, exposing a tethered ligand that binds intramolecularly to initiate signaling. Primarily expressed in epithelial, endothelial, and immune cells, PAR2 plays roles in inflammation, pain, tissue repair, and cancer progression. It is activated by serine proteases (e.g., trypsin, mast cell tryptase) and bacterial proteases, as well as by synthetic peptides mimicking the tethered ligand sequence. PAR2 signaling involves multiple pathways, including ERK, NF-κB, and calcium mobilization, influencing cellular responses like cytokine release and barrier function modulation.

PAR2 antibodies are critical tools for detecting receptor expression, localization, and activation states in research. They enable studies of PAR2's pathophysiological roles, such as its dual pro- and anti-inflammatory effects, contribution to chronic pain, and paradoxical roles in cancer (promoting tumor growth or suppression depending on context). Challenges in antibody development include distinguishing between cleaved/activated and inactive receptor forms, as well as avoiding cross-reactivity with other PAR family members. Therapeutic PAR2-targeting antibodies are being explored for conditions like inflammatory bowel disease, arthritis, and metastatic cancers, though clinical translation remains limited. Recent advances focus on developing neutralizing antibodies or biased ligands to fine-tune downstream signaling for improved therapeutic specificity.