TransferrinReceptor2抗体;TransferrinReceptor2 Antibody—艾普蒂 新品

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     Western blot analysis of Transferrin Receptor 2 expression in HepG2 cell lysate.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

The transferrin receptor 2 (TfR2) antibody is a crucial tool for studying iron metabolism and related disorders. TfR2. a member of the transferrin receptor family, is primarily expressed in the liver, particularly in hepatocytes, and plays a regulatory role in systemic iron homeostasis. Unlike TfR1. which is ubiquitously expressed and mediates cellular iron uptake, TfR2 interacts with HFE protein to modulate hepcidin expression, a hormone controlling iron absorption and recycling. Dysregulation of TfR2 is linked to hereditary hemochromatosis, iron overload disorders, and hepatocellular carcinoma.

TfR2 antibodies are designed to detect specific epitopes on the TfR2 protein, enabling researchers to study its expression, localization, and function. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to analyze tissue-specific or disease-associated TfR2 expression patterns. Some antibodies target extracellular domains for cell surface detection, while others recognize intracellular regions for signaling studies. Validated TfR2 antibodies often undergo knockout cell line verification to ensure specificity, given the structural similarities between TfR2 and TfR1. Recent studies employ TfR2 antibodies to explore its role in iron-sensing pathways, cancer progression, and therapeutic targeting. Commercial variants include monoclonal and polyclonal formats from hosts like rabbit or mouse, optimized for different experimental applications.