AnnexinIV抗体;AnnexinIV Antibody—艾普蒂 新品

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     Western blot analysis of Annexin IV expression in HepG2 cell lysate.    

  
  

Annexin IV (ANXA4), a member of the annexin family, is a calcium-dependent phospholipid-binding protein involved in membrane-related processes such as vesicle trafficking, exocytosis, and apoptosis. It is encoded by the ANXA4 gene and structurally characterized by a conserved C-terminal core domain for calcium/membrane interactions and a variable N-terminal region. Annexin IV is expressed in normal tissues, including the gastrointestinal tract, kidneys, and placenta, and is implicated in regulating ion channels and maintaining epithelial barrier function.

In cancer research, Annexin IV is frequently overexpressed in malignancies like colorectal, pancreatic, and ovarian cancers, where it is associated with chemoresistance and metastasis. Its role in cancer progression involves modulating apoptosis evasion, extracellular matrix remodeling, and drug efflux mechanisms.

Annexin IV antibodies are essential tools for studying these functions, enabling the detection and quantification of the protein via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies aid in exploring its diagnostic or prognostic potential in cancer and understanding its physiological roles in membrane dynamics and cellular signaling. Researchers must validate antibody specificity for ANXA4. as cross-reactivity with other annexins is common. Host species (e.g., rabbit, mouse) and clonal types (monoclonal/polyclonal) are selected based on experimental requirements.