Frizzled8抗体;Frizzled8 Antibody—艾普蒂 新品

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of Frizzled 8 expression in Jurkat cell lysate.    

  
  

Frizzled8 (FZD8) antibodies are essential tools for studying the Frizzled family of receptors, which play a central role in Wnt signaling pathways. FZD8 is a seven-transmembrane G protein-coupled receptor that binds Wnt proteins, initiating both canonical (β-catenin-dependent) and non-canonical (β-catenin-independent) signaling cascades. These pathways regulate critical biological processes, including embryonic development, cell proliferation, differentiation, and tissue homeostasis. Dysregulation of FZD8 expression or function has been implicated in various diseases, particularly cancers (e.g., colorectal, breast) and developmental disorders.

FZD8 antibodies are designed to detect and quantify FZD8 protein levels, localize its expression in tissues or cells, and modulate its activity in functional assays. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Additionally, FZD8-specific antibodies can block receptor-ligand interactions, aiding in mechanistic studies of Wnt signaling or drug discovery targeting FZD8-associated pathologies.

Many commercially available FZD8 antibodies are monoclonal or polyclonal, validated for specificity through knockout cell lines or siRNA-mediated knockdown. Researchers must select antibodies based on application requirements, epitope regions, and cross-reactivity with other FZD isoforms. As Wnt signaling gains attention in cancer therapy and regenerative medicine, FZD8 antibodies remain vital for unraveling its role in disease mechanisms and therapeutic targeting.