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HCadherin抗体;HCadherin Antibody—艾普蒂新品

Rabbit Monoclonal HCadherin Antibody

询价 20μl 起订

50μl 起订

100μl 起订

上海更新日期：2025-05-30

上海切尔齐生物科技有限公司

非会员

联系人：周***

电话：027***

手机：180***

邮箱：nuo***

产品详情:

中文名称：: HCadherin抗体

英文名称：: Rabbit Monoclonal HCadherin Antibody

品牌：: 艾普蒂

产地：: 武汉

保存条件：: Stored at -20°C for 8658 year. Avoid repeated freeze / thaw cycles.

产品类别：: 抗体

重组：: 否

应用：: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA

种属反应性：: Human,Mouse,Rat

宿主：: Rabbit

偶联物：: 无

靶点：: HCadherin

验证与应用

应用及物种

WB	1/1000-1/2000	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	1/100-1/200	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	咨询技术	Human,Mouse,Rat

产品详情

Aliases	CDH13; CDHH; H-cadherin; Heart cadherin; P105; T cad; T Cadherin; Truncated cadherin;;Cadherin 13
WB Predicted band size	Calculated MW: 78 kDa ; Observed MW: 105,130 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	A synthesized peptide derived from human Cadherin 13
Formulation	Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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Western blot analysis of H Cadherin expression in Human fetal heart lysate.
Immunohistochemical analysis of paraffin-embedded Mouse skeletal muscle, using the Antibody at 1:100 dilution.
Immunohistochemical analysis of paraffin-embedded Human cervical cancer, using the Antibody at 1:100 dilution.
Immunohistochemical analysis of paraffin-embedded Human squamous cell carcinoma , using the Antibody at 1:100 dilution.

参考文献

以下是3篇关于H-Cadherin(Cadherin-13/CDH13)抗体的参考文献及其摘要概括：

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1. **文献名称**: *"CDH13 promoter methylation regulates cisplatin resistance of non-small cell lung cancer cells"*

**作者**: Li et al. (2018)

**摘要**: 研究利用抗H-Cadherin抗体分析肺癌细胞中CDH13的表达，发现其启动子甲基化通过抑制H-Cadherin蛋白表达增强癌细胞对顺铂的耐药性，提示CDH13可作为化疗敏感性标志物。

2. **文献名称**: *"H-Cadherin Expression is Associated with Angiogenesis in Triple-Negative Breast Cancer"*

**作者**: Smith et al. (2020)

**摘要**: 通过免疫组化(使用H-Cadherin单克隆抗体)发现，H-Cadherin在三阴性乳腺癌中高表达且与血管生成相关，抗体验证为靶向治疗提供潜在方向。

3. **文献名称**: *"A Novel Monoclonal Antibody Targeting H-Cadherin Enhances Neurite Outgrowth in vitro"*

**作者**: Tanaka et al. (2016)

**摘要**: 报道一种新型H-Cadherin单克隆抗体的开发，该抗体特异性识别神经元中的H-Cadherin，实验证明其促进神经突生长，可能用于神经再生研究。

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注：以上文献为示例，实际引用时需核对真实来源及作者信息。如需精准文献，建议通过PubMed或Web of Science以关键词(如"H-Cadherin antibody"、"CDH13 immunohistochemistry")检索近年研究。

背景信息

HCadherin, also known as Cadherin-13 or CDH13. is a member of the cadherin superfamily of calcium-dependent cell-cell adhesion proteins. Unlike classical cadherins, it is classified as a T-cadherin due to its unique structure, lacking transmembrane and cytoplasmic domains, instead anchoring to the cell membrane via a glycosylphosphatidylinositol (GPI) moiety. Primarily expressed in cardiovascular tissues, the nervous system, and endothelial cells, HCadherin plays critical roles in tissue morphogenesis, neuronal connectivity, and vascular remodeling. It regulates cell migration, proliferation, and signaling pathways, including interactions with lipoprotein receptors and growth factors.

Antibodies targeting HCadherin are essential tools for investigating its spatial expression, functional mechanisms, and involvement in diseases. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and flow cytometry. In research, they have revealed HCadherin's dual role in cancer—acting as a tumor suppressor in some contexts (e.g., inhibiting angiogenesis) while promoting metastasis in others. Its dysregulation is also linked to cardiovascular disorders, neuropsychiatric conditions, and metabolic syndromes.

Commercially available HCadherin antibodies are typically validated for specificity across human, mouse, and rat models. Researchers prioritize antibodies with well-documented clonal specificity (e.g., clone 16G5), host species compatibility (commonly rabbit or mouse), and application-optimized validation. Reliable antibodies underpin studies exploring HCadherin's potential as a therapeutic target or biomarker in atherosclerosis, Alzheimer's disease, and cancer progression.

HCadherin抗体;HCadherin;HCadherin Antibody;

公司简介

生物技术有限公司

成立日期	(2年)
注册资本	20万人民币
员工人数	1-10人
年营业额	￥ 100万以内
经营模式	贸易,工厂,试剂,定制,服务
主营行业	抗体,植物生物技术,细胞培养,蛋白组学