GCDFP15抗体;GCDFP15 Antibody—艾普蒂

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     Western blot analysis of GCDFP 15 expression in T47D cell lysate.    

  
  

GCDFP15 (Gross Cystic Disease Fluid Protein 15), also known as BRST-2 or prolactin-inducible protein (PIP), is a 15 kDa glycoprotein primarily expressed in apocrine secretory cells of the breast, salivary glands, sweat glands, and prostate. It functions in lubrication, immune modulation, and steroid hormone binding. As a tumor marker, GCDFP15 is highly specific for mammary origin, making it a valuable target in diagnostic pathology. The GCDFP15 antibody is a monoclonal or polyclonal reagent used to detect this protein in tissue samples via immunohistochemistry (IHC).

In clinical practice, GCDFP15 antibody aids in identifying primary or metastatic breast carcinomas, particularly hormone receptor-positive and HER2-negative subtypes. It helps differentiate breast cancer metastases from other adenocarcinomas (e.g., lung, ovarian) and confirms apocrine differentiation in breast lesions. While its sensitivity is moderate (~50–70% in breast cancers), its high specificity (>90%) complements other markers like GATA3. Limitations include reduced expression in triple-negative or high-grade tumors and occasional cross-reactivity with salivary or skin adnexal tissues. Recent studies also explore its role in prognostication and therapy response. Overall, GCDFP15 antibody remains a cornerstone in diagnostic algorithms for tumors of uncertain origin.