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  • PLAP抗体;PLAP Antibody—艾普蒂
  • PLAP抗体;PLAP Antibody—艾普蒂
  • PLAP抗体;PLAP Antibody—艾普蒂

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PLAP抗体;PLAP Antibody—艾普蒂

Rabbit Monoclonal PLAP Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-30

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：nuo***

产品详情:

中文名称：
PLAP抗体
英文名称：
Rabbit Monoclonal PLAP Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 8741 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
PLAP

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF1/20-1/50 Human,Mouse,Rat
IHCIHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesGlycerophosphatase; PLA2P; Plaa; PLAP;;PLAP
WB Predicted band sizeCalculated MW: 87 kDa ; Observed MW: 75 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human PLAP
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

+ +

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       Western blot analysis of PLAP expression in MCF7 cell lysate.    


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       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


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       Immunoprecipitate (IP) analysis using the Antibody at 1:50 dilution. (wb at 1:3K dilution)    


           

参考文献

以下为3篇关于PLAP抗体的参考文献摘要概括：

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1. **文献名称**: *Immunohistochemical localization of placental alkaline phosphatase in primary ovarian neoplasms*

**作者**: Kurman RJ, et al.

**摘要**: 研究通过免疫组化分析PLAP在卵巢肿瘤中的表达，发现其在生殖细胞肿瘤(如无性细胞瘤)中高表达，可作为鉴别诊断的生物标志物，尤其在区分卵巢癌亚型中具有临床价值。

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2. **文献名称**: *PLAP as a biomarker for testicular germ cell tumors: A comparative study with other markers*

**作者**: Ulbright TM, et al.

**摘要**: 比较PLAP与其他标志物(如AFP、hCG)在睾丸生殖细胞肿瘤中的敏感性及特异性，证实PLAP抗体在精原细胞瘤中的高特异性，提出其在病理诊断和分期中的辅助作用。

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3. **文献名称**: *Technical evaluation of PLAP antibody in modern immunohistochemistry platforms*

**作者**: Shi M, et al.

**摘要**: 评估不同商业化PLAP抗体在自动化免疫组化平台上的表现，优化染色条件以提高检测灵敏度，强调标准化操作对临床诊断结果一致性的重要性。

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如有需要具体文献来源(期刊卷期等)，可进一步补充说明。

       

背景信息

Placental alkaline phosphatase (PLAP) is a heat-stable isoenzyme belonging to the alkaline phosphatase family, primarily expressed in the placenta during pregnancy. It plays a role in nutrient absorption and cellular differentiation during embryogenesis. Structurally, PLAP is a glycosylphosphatidylinositol (GPI)-anchored membrane protein encoded by the ALPP gene on chromosome 2. While its expression diminishes in most adult tissues, trace levels may persist in the cervix, testes, and thymus.

Clinically, PLAP serves as a tumor marker due to its ectopic expression in various malignancies. It is notably elevated in germ cell tumors (e.g., seminomas, dysgerminomas) and certain carcinomas, including ovarian, gastrointestinal, and lung cancers. PLAP antibodies are widely employed in immunohistochemistry (IHC) to detect PLAP in tissue samples, aiding in differential diagnosis and tumor classification. However, its specificity is limited as PLAP may also be expressed in non-neoplastic conditions like inflammatory bowel disease.

Research continues to explore PLAP's role in cancer biology and its potential as a therapeutic target. Recent studies suggest its involvement in cell adhesion and drug resistance mechanisms. Despite advances, distinguishing PLAP from other alkaline phosphatase isoenzymes (e.g., intestinal or tissue-nonspecific types) remains crucial for accurate diagnostic interpretation.

       
PLAP抗体;PLAP;PLAP Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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