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网站主页 2B4/CD244, Mouse, 重组蛋白 (His) 2B4/CD244, Mouse, 重组蛋白 (His)
  • 2B4/CD244, Mouse, 重组蛋白 (His)|TMPJ-01086|TargetMol

2B4/CD244, Mouse, 重组蛋白 (His)|TMPJ-01086|TargetMol

2B4/CD244 Protein, Mouse, Recombinant (His)
17300 1mg 起订
上海 更新日期:2026-04-07

TargetMol中国(陶术生物)

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联系人:邵小姐
手机:15002134094 拨打
邮箱:marketing@targetmol.cn

产品详情:

中文名称:
2B4/CD244, Mouse, 重组蛋白 (His)
英文名称:
2B4/CD244 Protein, Mouse, Recombinant (His)
品牌:
TargetMol
产地:
美国
保存条件:
Shipping with blue ice/Shipping at ambient temperature.
产品类别:
抑制剂
货号:
TMPJ-01086

Product Introduction

Bioactivity

名称2B4/CD244 Protein, Mouse, Recombinant (His)
描述Natural killer cell receptor 2B4 (2B4/CD244)is a 66 kDa type I transmembrane glycoprotein in the SLAM subgroup of the CD2 protein family. SLAM family proteins have an extracellular domain (ECD) with two or four Ig-like domains and at least two cytoplasmic immunoreceptor tyrosine-based switch motifs (ITSMs). 2B4 interacts with CD48, while other SLAM family proteins interact in a homophilic manner. The mouse 2B4 cDNA encodes a 397 amino acid (aa) precursor that includes a 19 aa signal sequence, a 207 aa ECD with one Ig-like V-type and one C2-type Ig-like domain, a 21 aa transmembrane segment, and a 150 aa cytoplasmic domain with four ITSMs. Within the ECD, mouse 2B4 shares 46% and 68% aa sequence identity with human and rat 2B4, respectively. 2B4/CD48 signaling cooperates with other receptor systems to either promote or inhibit NK and CD8+ T cell activation. The inhibitory activities are distinct from those of MHC I restricted inhibitory NK cell receptors. Ligation of 2B4 with antibodies or CD48 constructs can directly trigger inhibitory signaling or disrupt an inhibitory interaction, leading to cellular activation. 2B4 can also induce signaling through CD48.
存储条件Shipping with blue ice/Shipping at ambient temperature.
关键字SLAMF-4 | SLAMF 4 | CD-244 | CD 244
SLAMF4|||SLAM family member 4|||Signaling lymphocytic activation molecule 4|||NKR2B4|||NK cell type I receptor protein 2B4|||Natural killer cell receptor 2B4|||CD244|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿,致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区,已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库,以及多种类型的生化试剂产品,包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等,此外,我们还建设有CADD(计算机辅助药物设计)研究中心、药理实验室、药化合成平台三大技术中心,全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持,我们将有效帮助您缩短研发周期,取得更成功的结果。

成立日期 (13年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ¥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,天然产物,生物化工,化学试剂,生物技术服务

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