单克隆Anti-Tau抗体-ACROBiosystems百普赛斯 新品

Monoclonal Anti-Human Phospho-Tau (Thr181) Antibody, Mouse IgG2a (8D8C10)

抗体来源（Source）

Monoclonal Anti-Human Phospho-Tau (Thr181) Antibody, Mouse IgG2a (8D8C10) is a Mouse monoclonal antibody produced from a hybridoma created by fusing SP2/0 myeloma and Mouse B-lymphocytes.

克隆号（Clone）

8D8C10

种属（Species）

Mouse

亚型（Isotype）

Mouse IgG2a | Mouse Kappa

偶联（Conjugate）

Unconjugated

抗体类型（Antibody Type）

Hybridoma Monoclonal

种属反应性（Reactivity）

Human

免疫原（Immunogen）

Recombinant polypeptide protein

特异性（Specificity）

Specifically recognizes Human p-tau181 Protein.

应用（Application）

纯度（Purity）

95% as determined by SDS-PAGE.

纯化（Purification）

Protein A purified / Protein G purified

制剂（Formulation）

Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

Please contact us for customized product forms or formulations.

重构方法（Reconstitution）

Please refer to the Certificate of Analysis (CoA) for specific instructions.

For best performance, we strongly recommend following the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景介绍

Tau蛋白是一种微管相关蛋白，在阿尔茨海默病（AD）及相关tau蛋白病中会形成不溶性纤维，并聚积为神经原纤维缠结。在生理条件下，Tau蛋白调控微管的组装并维持其结构稳定性。然而，在病变大脑中，Tau蛋白会出现异常过度磷酸化，最终导致微管解聚，游离的Tau蛋白分子聚集成螺旋细丝。