单克隆Anti-Glycoprotein C/gC (HSV)抗体 新品

Monoclonal Anti-gC-HSV-2 (strain 333) Antibody, Mouse IgG1 (3A12) (MALS verified)

抗体来源（Source）

Monoclonal Anti-gC-HSV-2 (strain 333) Antibody, Mouse IgG1 (3A12) is a Mouse monoclonal antibody produced from a hybridoma created by fusing SP2/0 myeloma and Mouse B-lymphocytes.

克隆号（Clone）

3A12

种属（Species）

Mouse

亚型（Isotype）

Mouse IgG1 | Mouse Kappa

偶联（Conjugate）

Unconjugated

抗体类型（Antibody Type）

Hybridoma Monoclonal

种属反应性（Reactivity）

Virus

免疫原（Immunogen）

Recombinant HSV-2 (strain 333) Envelope Glycoprotein C (gC) derived from human 293 cells

特异性（Specificity）

This product is a specific antibody specifically reacts with Glycoprotein C/gC (HSV).

应用（Application）

纯度（Purity）

95% as determined by SDS-PAGE.

90% as determined by SEC-MALS.

纯化（Purification）

Protein A purified / Protein G purified

制剂（Formulation）

Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

Please contact us for customized product forms or formulations.

重构方法（Reconstitution）

Please refer to the Certificate of Analysis (CoA) for specific instructions.

For best performance, we strongly recommend following the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景介绍

疱疹病毒感染在全球人群中广泛传播。单纯疱疹病毒（HSV）属于α-疱疹病毒亚科。感染人类的HSV主要有两种类型：HSV-1和HSV-2。HSV-2主要引起生殖器病变，而HSV-1则可导致口腔及生殖器感染。糖蛋白C（gC）是单纯疱疹病毒2型（HSV-2）包膜的结构成分，介导病毒与细胞表面硫酸乙酰肝素或硫酸软骨素的结合。此外，它还能通过抑制宿主补体级联反应的激活，在宿主免疫逃逸中发挥作用（根据相似性推测）。