单克隆Anti-B2M抗体, Mouse IgG2b 新品

PE-Labeled Monoclonal Anti-B2M Antibody, Mouse IgG2b (0.03% Proclin)

抗体来源（Source）

PE-Labeled Monoclonal Anti-B2M Antibody, Mouse IgG2b is a mouse monoclonal antibody recombinantly expressed from human 293 cells (HEK293), which provides higher batch consistency and long term security of supply.

应用（Application）

Flow Cytometry (Evaluation of an epitope within the extracellular domain of human B2M protein).

种属（Species）

Mouse

亚型（Isotype）

Mouse IgG2b | Mouse kappa

特异性（Specificity）

Clone BBM.1 detects Beta-2-microglobulin in human.

种属反应性（Reactivity）

Human

免疫原（Immunogen）

MOLT-4, a Human acute lymphoblastic leukemia cell line

偶联（Conjugate）

PE

Excitation Wavelength: 488 nm / 561 nm

Emission Wavelength: 575 nm

同型对照（Isotype Control）

The isotype control is sold separately; please refer to Cat. No. DNP-PM486 for product information.

推荐稀释比（Recommended Dilution）

1:50

制剂（Formulation）

Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4) containing 0.03% ProClin 300 and 0.2% BSA, with trehalose as protectant.

Please contact us for customized product forms or formulations.

重构方法（Reconstitution）

Please refer to the Certificate of Analysis (CoA) for specific instructions.

For best performance, we strongly recommend following the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

Please protect from light and avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 24 months in lyophilized state;

-70°C for 12 months after reconstitution.

2-8 °C for 12 months after reconstitution.

背景介绍

β2-微球蛋白（B2M）是主要组织相容性复合体I类（MHC I类）分子的组成成分，参与将肽抗原呈递给免疫系统。B2M由两个通过二硫键连接的β折叠片组成，在某些病理条件下可形成淀粉样纤维。越来越多的证据表明，肿瘤细胞中B2M基因的改变可能通过阻碍MHC I类分子介导的肿瘤抗原呈递以及帮助肿瘤细胞逃避T细胞识别，从而降低基于T细胞的免疫疗法的疗效。