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Is 1,1,3,3-tetramethyldisiloxane a reducing agent?

Apr 17,2026

Yes. 1,1,3,3-Tetramethyldisiloxane (TMDS) can be used as a reducing agent in the reductive N-alkylation of amides. In this reaction, using carbonyl compounds (such as aldehydes and ketones) as alkylating agents, a range of substrates—including aromatic, aliphatic and cinnamoyl amides, as well as γ-lactams—can yield the corresponding alkylated amides in moderate to high yields.

Lastest Price from 1,1,3,3-Tetramethyldisiloxane manufacturers

1,1,3,3-Tetramethyldisiloxane
3277-26-7 1,1,3,3-Tetramethyldisiloxane
US $0.00/kg2025-06-12
CAS:
3277-26-7
Min. Order:
1kg
Purity:
99% Min.
Supply Ability:
20mt per month
1,1,3,3 tetramethyl
3277-26-7 1,1,3,3 tetramethyl
US $0.00/KG2025-04-21
CAS:
3277-26-7
Min. Order:
1KG
Purity:
99%
Supply Ability:
10 mt