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Is Lithium diisopropylamide (LDA) a strong Nucleophilic strong base? What reactions can it undergo?

Apr 17,2026

Yes! Lithium diisopropylamide (LDA) is a strong Nucleophilic strong base. Does not give nucleophile substitutioneven with alkyl halides tosylates. LDA is applied in direct alkylation and acylation of ketones, aiding in the formation of enolates and enabling reactions such as aldol condensation.Lithium diisopropylamide is widely used as a reagent in the preparation ofLDA has a low solubility and irreversibly precipitates in hydrocarbon solvents.

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Lastest Price from Lithium diisopropylamide manufacturers

Lithium diisopropylamide
4111-54-0 Lithium diisopropylamide
US $10.00/ASSAYS2025-08-21
CAS:
4111-54-0
Min. Order:
1ASSAYS
Purity:
99%
Supply Ability:
1 ton
Lithium diisopropylamide
4111-54-0 Lithium diisopropylamide
US $10.00/KG2025-04-21
CAS:
4111-54-0
Min. Order:
1KG
Purity:
99%
Supply Ability:
100 mt