Is Propylene Glycol safe for Skin? What are its side effects?

Propylene glycol is designated as a Generally Recognized As Safe (GRAS) additive by the Food and Drug Administration (FDA) and is widely used in commercial formulations of foods, drugs, and cosmetics. Propylene glycol is a common ingredient that is used as a vehicle for different cosmetics and therapeutics, usually as an emollient and an emulsifier. Oral exposure to the small amounts of propylene glycol found in foods and drugs is unlikely to cause toxic effects. Central nervous system depression, hematologic toxicity, hyperosmolarity, metabolic acidosis, cardiovascular effects, and renal toxicity encompass the main acute and subacute syndromes for propylene glycol.

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