What are the negatives of allopurinol?

Common negative effects of allopurinol include mild digestive issues such as nausea, diarrhea, and stomach discomfort, as well as headaches, rashes, and temporary gout flare‑ups at the start of treatment; more serious but rare risks involve severe allergic skin reactions like Stevens-Johnson syndrome, liver or kidney dysfunction, low blood cell counts, and hypersensitivity reactions that can be life‑threatening, especially in patients with poor kidney function or certain genetic predispositions.

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