What is HATU used for? Is it highly toxic?

HATU, the N-guanidium salt of HOAt, used as a reagent for amide coupling reactions. HATU showed no mortality, but limited toxicity, to rats when dosed at 2000 mg kg−1 via the oral route. HATU was not a skin irritant in rabbits. In rabbits, HATU was found to be a slight eye irritant. Studies in guinea pigs revealed that HATU induced contact allergy.

You may like