What is the most common side effect of cisplatin?

The most common side effect of cisplatin, a widely used platinum-based chemotherapeutic agent, is nephrotoxicity, or kidney damage, which arises from the drug’s accumulation in renal tubular cells and subsequent oxidative stress and cellular injury; this renal toxicity is typically dose-dependent and can manifest as reduced glomerular filtration rate, electrolyte imbalances (such as hypomagnesemia and hypokalemia), and acute kidney injury if not properly managed, making pre-treatment hydration and diuresis standard clinical interventions to mitigate this adverse effect.

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