What is uses and synthesis of 2-Chloronicotinic acid?

2-Chloronicotinic acid is a halogenated derivative of nicotinic acid that is used as an intermediate in the production of a variety of bioactive compounds, including boscalid and diflufenican.The synthesis of 2-Chloronicotinic acid: 2-chloronicotinic acid chloride is distilled off from the nicotinic acid-N-oxide reaction mixture and the distillate is allowed to flow into water at a temperature of 40° to 100° C., whereby the 2-chloronicotinic acid chloride is hydrolyzed to the 2-chloronicotinic acid, which precipitates in a pure white crystalline form.

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